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Citation
Foo, L.C., Song, S., Cohen, S.M. (2017). miR-31 mutants reveal continuous glial homeostasis in the adult Drosophila brain.  EMBO J. 36(9): 1215--1226.
FlyBase ID
FBrf0235434
Publication Type
Research paper
Abstract

The study of adult neural cell production has concentrated on neurogenesis. The mechanisms controlling adult gliogenesis are still poorly understood. Here, we provide evidence for a homeostatic process that maintains the population of glial cells in the Drosophila adult brain. Flies lacking microRNA miR-31a start adult life with a normal complement of glia, but transiently lose glia due to apoptosis. miR-31a expression identifies a subset of predominantly gliogenic adult neural progenitor cells. Failure to limit expression of the predicted E3 ubiquitin ligase, Rchy1, in these cells results in glial loss. After an initial decline in young adults, glial numbers recovered due to compensatory overproduction of new glia by adult progenitor cells, indicating an unexpected plasticity of the Drosophila nervous system. Experimentally induced ablation of glia was also followed by recovery of glia over time. These studies provide evidence for a homeostatic mechanism that maintains the number of glia in the adult fly brain.

PubMed ID
PubMed Central ID
PMC5412881 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

mir-31a insertions.
Foo, 2017.8.7, mir-31a insertions. [FBrf0236305]

Location data for the mir-31a[KO.RMCE]-associated deletion.
Foo and Cohen, 2018.6.28, Location data for the mir-31a[KO.RMCE]-associated deletion. [FBrf0239340]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference