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Citation
Liang, X., Holy, T.E., Taghert, P.H. (2017). A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs.  Neuron 94(6): 1173--1189.e4.
FlyBase ID
FBrf0235909
Publication Type
Research paper
Abstract

We studied the Drosophila circadian neural circuit using whole-brain imaging in vivo. Five major groups of pacemaker neurons display synchronized molecular clocks, yet each exhibits a distinct phase of daily Ca(2+) activation. Light and neuropeptide pigment dispersing factor (PDF) from morning cells (s-LNv) together delay the phase of the evening (LNd) group by ∼12 hr; PDF alone delays the phase of the DN3 group by ∼17 hr. Neuropeptide sNPF, released from s-LNv and LNd pacemakers, produces Ca(2+) activation in the DN1 group late in the night. The circuit also features negative feedback by PDF to truncate the s-LNv Ca(2+) wave and terminate PDF release. Both PDF and sNPF suppress basal Ca(2+) levels in target pacemakers with long durations by cell-autonomous actions. Thus, light and neuropeptides act dynamically at distinct hubs of the circuit to produce multiple suppressive events that create the proper tempo and sequence of circadian pacemaker neuronal activities.

PubMed ID
PubMed Central ID
PMC5502710 (PMC) (EuropePMC)
Related Publication(s)
Note

Staring at the Clock Face in Drosophila.
Rosato and Kyriacou, 2017, Neuron 94(6): 1046--1048 [FBrf0236008]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference