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Citation
King, A.N., Barber, A.F., Smith, A.E., Dreyer, A.P., Sitaraman, D., Nitabach, M.N., Cavanaugh, D.J., Sehgal, A. (2017). A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.  Curr. Biol. 27(13): 1915--1927.e5.
FlyBase ID
FBrf0236052
Publication Type
Research paper
Abstract

The mechanisms by which clock neurons in the Drosophila brain confer an ∼24-hr rhythm onto locomotor activity are unclear, but involve the neuropeptide diuretic hormone 44 (DH44), an ortholog of corticotropin-releasing factor. Here we identified DH44 receptor 1 as the relevant receptor for rest:activity rhythms and mapped its site of action to hugin-expressing neurons in the subesophageal zone (SEZ). We traced a circuit that extends from Dh44-expressing neurons in the pars intercerebralis (PI) through hugin+ SEZ neurons to the ventral nerve cord. Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion. These findings define a linear peptidergic circuit that links the clock to motor outputs to modulate circadian control of locomotor activity.

PubMed ID
PubMed Central ID
PMC5698909 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for Dh44-R1[DsRed] deletion.
King and Sehgal, 2017.12.13, Location data for Dh44-R1[DsRed] deletion. [FBrf0237688]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Aberrations (2)
    Alleles (42)
    Genes (18)
    Sequence Features (1)
    Natural transposons (1)
    Insertions (6)
    Experimental Tools (5)
    Transgenic Constructs (36)
    Transcripts (10)