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Citation
Tan, F.H.P., Azzam, G. (2017). Drosophila melanogaster: Deciphering Alzheimer's Disease.  Malays. J. Med. Sci. 24(2): 6--20.
FlyBase ID
FBrf0236630
Publication Type
Review
Abstract

Alzheimer's disease (AD) is the most widespread neurodegenerative disorder worldwide. Its pathogenesis involves two hallmarks: aggregation of amyloid beta (Aβ) and occurrence of neurofibrillary tangles (NFTs). The mechanism behind the disease is still unknown. This has prompted the use of animal models to mirror the disease. The fruit fly, Drosophila melanogaster has garnered considerable attention as an organism to recapitulate human disorders. With the ability to monopolise a multitude of traditional and novel genetic tools, Drosophila is ideal for studying not only cellular aspects but also physiological and behavioural traits of human neurodegenerative diseases. Here, we discuss the use of the Drosophila model in understanding AD pathology and the insights gained in discovering drug therapies for AD.

PubMed ID
PubMed Central ID
PMC5566057 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Malays. J. Med. Sci.
    Title
    The Malaysian journal of medical sciences
    ISBN/ISSN
    1394-195X 2180-4303
    Data From Reference
    Genes (7)
    Human Disease Models (3)