Open Close
Reference
Citation
Kondo, S., Vedanayagam, J., Mohammed, J., Eizadshenass, S., Kan, L., Pang, N., Aradhya, R., Siepel, A., Steinhauer, J., Lai, E.C. (2017). New genes often acquire male-specific functions but rarely become essential in Drosophila.  Genes Dev. 31(18): 1841--1846.
FlyBase ID
FBrf0236926
Publication Type
Research paper
Abstract
Relatively little is known about the in vivo functions of newly emerging genes, especially in metazoans. Although prior RNAi studies reported prevalent lethality among young gene knockdowns, our phylogenomic analyses reveal that young Drosophila genes are frequently restricted to the nonessential male reproductive system. We performed large-scale CRISPR/Cas9 mutagenesis of "conserved, essential" and "young, RNAi-lethal" genes and broadly confirmed the lethality of the former but the viability of the latter. Nevertheless, certain young gene mutants exhibit defective spermatogenesis and/or male sterility. Moreover, we detected widespread signatures of positive selection on young male-biased genes. Thus, young genes have a preferential impact on male reproductive system function.
PubMed ID
PubMed Central ID
PMC5695085 (PMC) (EuropePMC)
Related Publication(s)
Note
Out of the testis: biological impacts of new genes.
Nyberg and Carthew, 2017, Genes Dev. 31(18): 1825--1826 [FBrf0237016]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference