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Citation
Tusco, R., Jacomin, A.C., Jain, A., Penman, B.S., Larsen, K.B., Johansen, T., Nezis, I.P. (2017). Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses.  Nat. Commun. 8(1): 1264.
FlyBase ID
FBrf0237111
Publication Type
Research paper
Abstract

Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate immunity is still unclear. Here we show that Drosophila Kenny, the homolog of mammalian IKKγ, is a selective autophagy receptor that mediates the degradation of the IκB kinase complex. Selective autophagic degradation of the IκB kinase complex prevents constitutive activation of the immune deficiency pathway in response to commensal microbiota. We show that autophagy-deficient flies have a systemic innate immune response that promotes a hyperplasia phenotype in the midgut. Remarkably, human IKKγ does not interact with mammalian Atg8-family proteins. Using a mathematical model, we suggest mechanisms by which pathogen selection might have driven the loss of LIR motif functionality during evolution. Our results suggest that there may have been an autophagy-related switch during the evolution of the IKKγ proteins in metazoans.

PubMed ID
PubMed Central ID
PMC5668318 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Nezis insertions.
Nezis, 2020.5.1, Nezis insertions. [FBrf0245572]

Note

Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation.
Jacomin and Nezis, 2020, Mol. Cell. Oncol. 7(1): 1682309 [FBrf0244712]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference