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Citation
Hoedjes, K.M., Rodrigues, M.A., Flatt, T. (2017). Amino acid modulation of lifespan and reproduction in Drosophila.  Curr. Opin. Insect Sci. 23(): 118--122.
FlyBase ID
FBrf0237141
Publication Type
Review
Abstract

Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. Remarkably, AA manipulation can uncouple the commonly observed trade-off between these traits. This finding seems to challenge the idea that this trade-off is due to competitive resource allocation, but here we argue that this view might be too simplistic. We also discuss the mechanisms of the AA response, mediated by the IIS/TOR and GCN2 pathways. Elucidating how these pathways respond to specific AA will likely yield important insights into how AA modulate the reproduction-lifespan relationship. The Drosophila model offers powerful genetic tools, combined with options for precise diet manipulation, to address these fundamental questions.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Insect Sci.
    Title
    Current opinion in insect science
    ISBN/ISSN
    2214-5753 2214-5745
    Data From Reference
    Genes (6)