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Citation
Bahrampour, S., Gunnar, E., Jonsson, C., Ekman, H., Thor, S. (2017). Neural Lineage Progression Controlled by a Temporal Proliferation Program.  Dev. Cell 43(3): 332--348.e4.
FlyBase ID
FBrf0237144
Publication Type
Research paper
Abstract
Great progress has been made in identifying transcriptional programs that establish stem cell identity. In contrast, we have limited insight into how these programs are down-graded in a timely manner to halt proliferation and allow for cellular differentiation. Drosophila embryonic neuroblasts undergo such a temporal progression, initially dividing to bud off daughters that divide once (type I), then switching to generating non-dividing daughters (type 0), and finally exiting the cell cycle. We identify six early transcription factors that drive neuroblast and type I daughter proliferation. Early factors are gradually replaced by three late factors, acting to trigger the type I→0 daughter proliferation switch and eventually to stop neuroblasts. Early and late factors regulate each other and four key cell-cycle genes, providing a logical genetic pathway for these transitions. The identification of this extensive driver-stopper temporal program controlling neuroblast lineage progression may have implications for studies in many other systems.
Graphical Abstract
Obtained with permission from Cell Press.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (8)
    Alleles (35)
    Genes (22)
    Natural transposons (2)
    Insertions (20)
    Experimental Tools (4)
    Transgenic Constructs (20)