Open Close
Reference
Citation
Bi, C., Meng, F., Yang, L., Cheng, L., Wang, P., Chen, M., Fang, M., Xie, H. (2018). CtBP represses Dpp signaling as a dimer.  Biochem. Biophys. Res. Commun. 495(2): 1980--1985.
FlyBase ID
FBrf0237493
Publication Type
Research paper
Abstract

C-terminal binding protein (CtBP) is a highly conserved transcriptional co-repressor in animal development and human diseases. In Drosophila, CtBP is critical for fly development and is thought to exert its repressive roles in many signaling pathways including Dpp/BMP pathway. Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biochem. Biophys. Res. Commun.
    Title
    Biochemical and Biophysical Research Communications
    Publication Year
    1959-
    ISBN/ISSN
    0006-291X
    Data From Reference
    Alleles (6)
    Genes (2)
    Physical Interactions (1)
    Cell Lines (1)
    Natural transposons (1)
    Experimental Tools (2)
    Transgenic Constructs (6)