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Citation
Ma, X.X., Li, X., Yi, P., Wang, C., Weng, J., Zhang, L., Xu, X., Sun, H., Feng, S., Liu, K., Chen, R., Du, S., Mao, X., Zeng, X., Zhang, L.Y., Liu, M., Tang, B.S., Zhu, X., Jin, S., Liu, J.Y. (2017). PiT2 regulates neuronal outgrowth through interaction with microtubule-associated protein 1B.  Sci. Rep. 7(1): 17850.
FlyBase ID
FBrf0237660
Publication Type
Research paper
Abstract

PiT2 is a member of the inorganic phosphate transporter family, and is extensively expressed in the nervous system. It was found that loop7 domain of PiT2 is not required for retroviral recognition and transport function. The exact functions of loop7 remain poorly understood. Here we show that loop7 of PiT2 is necessary for the transport of PiT2 protein to the cell surface. Further, loop7 is also related to the outgrowth of neurite in Neuro2A cells interacts with the light chain 1 of microtubule-associated protein 1B (MAP1B). PiT2 with mutated MAP1B binding sites affect neurite outgrowth whereas Pi transport function deficient mutants of PiT2 do not. We also show that Drosophila dPiT interacts with microtubule-associated protein Futsch, and dPiT is crucial for the normal development of neuromuscular junctions (NMJs). These results indicate that PiT2 might participate in the regulation of neuronal outgrowth by interacting with MAP1B and independently of its Pi transport function in the nervous system.

PubMed ID
PubMed Central ID
PMC5736545 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for NaPi-III deletions.
Jin, 2018.6.29, Location data for NaPi-III deletions. [FBrf0244673]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference
    Aberrations (2)
    Alleles (9)
    Genes (3)
    Physical Interactions (2)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (5)