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Citation
Donlea, J.M., Pimentel, D., Talbot, C.B., Kempf, A., Omoto, J.J., Hartenstein, V., Miesenböck, G. (2018). Recurrent Circuitry for Balancing Sleep Need and Sleep.  Neuron 97(2): 378--389.e4.
FlyBase ID
FBrf0237798
Publication Type
Research paper
Abstract
Sleep-promoting neurons in the dorsal fan-shaped body (dFB) of Drosophila are integral to sleep homeostasis, but how these cells impose sleep on the organism is unknown. We report that dFB neurons communicate via inhibitory transmitters, including allatostatin-A (AstA), with interneurons connecting the superior arch with the ellipsoid body of the central complex. These "helicon cells" express the galanin receptor homolog AstA-R1, respond to visual input, gate locomotion, and are inhibited by AstA, suggesting that dFB neurons promote rest by suppressing visually guided movement. Sleep changes caused by enhanced or diminished allatostatinergic transmission from dFB neurons and by inhibition or optogenetic stimulation of helicon cells support this notion. Helicon cells provide excitation to R2 neurons of the ellipsoid body, whose activity-dependent plasticity signals rising sleep pressure to the dFB. By virtue of this autoregulatory loop, dFB-mediated inhibition interrupts processes that incur a sleep debt, allowing restorative sleep to rebalance the books. VIDEO ABSTRACT.
PubMed ID
PubMed Central ID
PMC5779612 (PMC) (EuropePMC)
Related Publication(s)
Note
Sleep: Helicon Cells Charge the Circuit.
Yurgel and Keene, 2018, Curr. Biol. 28(7): R317--RR319 [FBrf0238549]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference