FB2025_01 , released February 20, 2025
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Citation
Silva, J., Aivio, S., Knobel, P.A., Bailey, L.J., Casali, A., Vinaixa, M., Garcia-Cao, I., Coyaud, É., Jourdain, A.A., Pérez-Ferreros, P., Rojas, A.M., Antolin-Fontes, A., Samino-Gené, S., Raught, B., González-Reyes, A., Ribas de Pouplana, L., Doherty, A.J., Yanes, O., Stracker, T.H. (2018). EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.  Nat. Cell Biol. 20(2): 162--174.
FlyBase ID
FBrf0237913
Publication Type
Research paper
Abstract
Mitochondria are subcellular organelles that are critical for meeting the bioenergetic and biosynthetic needs of the cell. Mitochondrial function relies on genes and RNA species encoded both in the nucleus and mitochondria, and on their coordinated translation, import and respiratory complex assembly. Here, we characterize EXD2 (exonuclease 3'-5' domain-containing 2), a nuclear-encoded gene, and show that it is targeted to the mitochondria and prevents the aberrant association of messenger RNAs with the mitochondrial ribosome. Loss of EXD2 results in defective mitochondrial translation, impaired respiration, reduced ATP production, increased reactive oxygen species and widespread metabolic abnormalities. Depletion of the Drosophila melanogaster EXD2 orthologue (CG6744) causes developmental delays and premature female germline stem cell attrition, reduced fecundity and a dramatic extension of lifespan that is reversed with an antioxidant diet. Our results define a conserved role for EXD2 in mitochondrial translation that influences development and ageing.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Cell Biol.
    Title
    Nature Cell Biology
    Publication Year
    1999-
    ISBN/ISSN
    1465-7392 1476-4679
    Data From Reference
    Alleles (1)
    Chemicals (2)
    Genes (1)
    Cell Lines (1)