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Citation
Forest, E., Logeay, R., Géminard, C., Kantar, D., Frayssinoux, F., Heron-Milhavet, L., Djiane, A. (2018). The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs.  J. Cell Biol. 217(3): 1047--1062.
FlyBase ID
FBrf0238312
Publication Type
Research paper
Abstract

During development, cell numbers are tightly regulated, ensuring that tissues and organs reach their correct size and shape. Recent evidence has highlighted the intricate connections between the cytoskeleton and the regulation of the key growth control Hippo pathway. Looking for apical scaffolds regulating tissue growth, we describe that Drosophila melanogaster big bang (Bbg), a poorly characterized multi-PDZ scaffold, controls epithelial tissue growth without affecting epithelial polarity and architecture. bbg-mutant tissues are smaller, with fewer cells that are less apically constricted than normal. We show that Bbg binds to and colocalizes tightly with the β-heavy-Spectrin/Kst subunit at the apical cortex and promotes Yki activity, F-actin enrichment, and the phosphorylation of the myosin II regulatory light chain Spaghetti squash. We propose a model in which the spectrin cytoskeleton recruits Bbg to the cortex, where Bbg promotes actomyosin contractility to regulate epithelial tissue growth.

PubMed ID
PubMed Central ID
PMC5839784 (PMC) (EuropePMC)
Related Publication(s)
Note

The Big Bang of tissue growth: Apical cell constriction turns into tissue expansion.
Janody, 2018, J. Cell Biol. 217(3): 807--808 [FBrf0238366]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference