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Citation
VanKuren, N.W., Long, M. (2018). Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions.  Nat. Ecol. Evol. 2(4): 705--712.
FlyBase ID
FBrf0238441
Publication Type
Research paper
Abstract

Males and females have different fitness optima but share the vast majority of their genomes, causing an inherent genetic conflict between the two sexes that must be resolved to achieve maximal population fitness. We show that two tandem duplicate genes found specifically in Drosophila melanogaster are sexually antagonistic, but rapidly evolved sex-specific functions and expression patterns that mitigate their antagonistic effects. We use copy-specific knockouts and rescue experiments to show that Apollo (Apl) is essential for male fertility but detrimental to female fertility, in addition to its important role in development, while Artemis (Arts) is essential for female fertility but detrimental to male fertility. Further analyses show that Apl and Arts have essential roles in spermatogenesis and oogenesis. These duplicates formed ~200,000 years ago, underwent a strong selective sweep and lost most expression in the antagonized sex. These data provide direct evidence that gene duplication allowed rapid mitigation of sexual conflict by allowing Apl and Arts to evolve essential sex-specific reproductive functions and complementary expression in male and female gonads.

PubMed ID
PubMed Central ID
PMC5866764 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

P{UAS-Arts.RNAi} and P{UAS-Apl.RNAi} insertions.
Xia and Long, 2019.4.16, P{UAS-Arts.RNAi} and P{UAS-Apl.RNAi} insertions. [FBrf0242254]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Ecol. Evol.
    Title
    Nature ecology & evolution
    ISBN/ISSN
    2397-334X
    Data From Reference
    Alleles (10)
    Genes (6)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (6)