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Citation
Landskron, L., Steinmann, V., Bonnay, F., Burkard, T.R., Steinmann, J., Reichardt, I., Harzer, H., Laurenson, A.S., Reichert, H., Knoblich, J.A. (2018). The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.  eLife 7(): e31347.
FlyBase ID
FBrf0238522
Publication Type
Research paper
Abstract

Tumor cells display features that are not found in healthy cells. How they become immortal and how their specific features can be exploited to combat tumorigenesis are key questions in tumor biology. Here we describe the long non-coding RNA cherub that is critically required for the development of brain tumors in Drosophila but is dispensable for normal development. In mitotic Drosophila neural stem cells, cherub localizes to the cell periphery and segregates into the differentiating daughter cell. During tumorigenesis, de-differentiation of cherub-high cells leads to the formation of tumorigenic stem cells that accumulate abnormally high cherub levels. We show that cherub establishes a molecular link between the RNA-binding proteins Staufen and Syncrip. As Syncrip is part of the molecular machinery specifying temporal identity in neural stem cells, we propose that tumor cells proliferate indefinitely, because cherub accumulation no longer allows them to complete their temporal neurogenesis program.

PubMed ID
PubMed Central ID
PMC5871330 (PMC) (EuropePMC)
Related Publication(s)
Note

Stem Cell Tumors: Cherub versus brat.
Malin and Desplan, 2018, eLife 7: e36030 [FBrf0239539]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference