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Citation
Lefebvre, F.A., Lécuyer, É. (2018). Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development.  J. Dev. Biol. 6(1): E5.
FlyBase ID
FBrf0238607
Publication Type
Review
Abstract
Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes. Drosophila provides an elegant and genetically tractable system to investigate these conserved changes at a dazzling developmental pace. Here, we review recent studies applying emerging technologies such as ribosome profiling, in situ Hi-C chromatin probing and live embryo RNA imaging to investigate the transcriptional dynamics at play during Drosophila embryogenesis. In light of this new literature, we revisit the main models of zygotic genome activation (ZGA). We also review the contributions played by zygotic transcription in shaping embryogenesis and explore emerging concepts of processes such as transcriptional bursting and transcriptional memory.
PubMed ID
PubMed Central ID
PMC5875563 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Dev. Biol.
    Title
    Journal of developmental biology
    ISBN/ISSN
    2221-3759
    Data From Reference
    Genes (18)