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Citation
Richardson, H.E., Portela, M. (2018). Modelling Cooperative Tumorigenesis in Drosophila.  Biomed Res. Int. 2018(): 4258387.
FlyBase ID
FBrf0238689
Publication Type
Review
Abstract
The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
PubMed ID
PubMed Central ID
PMC5859872 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biomed Res. Int.
    Title
    BioMed research international
    ISBN/ISSN
    2314-6141 2314-6133
    Data From Reference