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Yamashiro, H., Siomi, M.C. (2018). PIWI-Interacting RNA in Drosophila: Biogenesis, Transposon Regulation, and Beyond.  Chem. Rev. 118(8): 4404--4421.
FlyBase ID
FBrf0238693
Publication Type
Review
Abstract

PIWI-interacting RNAs (piRNAs) are germline-enriched small RNAs that control transposons to maintain genome integrity. To achieve this, upon being processed from piRNA precursors, most of which are transcripts of intergenic piRNA clusters, piRNAs bind PIWI proteins, germline-specific Argonaute proteins, to form effector complexes. The mechanism of this piRNA-mediated transposon silencing pathway is fundamentally similar to that of siRNA/miRNA-dependent gene silencing in that a small RNA guides its partner Argonaute protein to target gene transcripts for repression via RNA-RNA base pairing. However, the uniqueness of this piRNA pathway has emerged through intensive genetic, biochemical, bioinformatic, and structural investigations. Here, we review the studies that elucidated the piRNA pathway, mainly in Drosophila, by describing both historical and recent progress. Studies in other species that have made important contributions to the field are also described.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Chem. Rev.
    Title
    Chemical Reviews
    Publication Year
    1924-
    ISBN/ISSN
    0009-2665
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