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Reference
Citation
Martin, M., Hiroyasu, A., Guzman, R.M., Roberts, S.A., Goodman, A.G. (2018). Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function.  Cell Rep. 23(12): 3537--3550.e6.
FlyBase ID
FBrf0239241
Publication Type
Research paper
Abstract

The vertebrate protein STING, an intracellular sensor of cyclic dinucleotides, is critical to the innate immune response and the induction of type I interferon during pathogenic infection. Here, we show that a STING ortholog (dmSTING) exists in Drosophila, which, similar to vertebrate STING, associates with cyclic dinucleotides to initiate an innate immune response. Following infection with Listeria monocytogenes, dmSTING activates an innate immune response via activation of the NF-κB transcription factor Relish, part of the immune deficiency (IMD) pathway. DmSTING-mediated activation of the immune response reduces the levels of Listeria-induced lethality and bacterial load in the host. Of significance, dmSTING triggers an innate immune response in the absence of a known functional cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) ortholog in the fly. Together, our results demonstrate that STING is an evolutionarily conserved antimicrobial effector between flies and mammals, and it comprises a key component of host defense against pathogenic infection in Drosophila.

PubMed ID
PubMed Central ID
PMC6114933 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for Sting deletions.
Goodman, 2019.1.24, Location data for Sting deletions. [FBrf0241310]

Note

STING: From Mammals to Insects.
Qiu and Zhou, 2018, Cell Host Microbe 24(1): 5--7 [FBrf0239491]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference
    Aberrations (1)
    Alleles (17)
    Genes (11)
    Cell Lines (2)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (11)