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Citation
Park, J.E., Lee, E.J., Kim, J.K., Song, Y., Choi, J.H., Kang, M.J. (2018). Flightless-I Controls Fat Storage in Drosophila.  Mol. Cells 41(6): 603--611.
FlyBase ID
FBrf0239319
Publication Type
Research paper
Abstract

Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the Drosophila flightless-I (fliI) gene in lipid metabolism. Drosophila fliI mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas fliI overexpression decreased triglyceride levels. These flies suffered from metabolic stress indicated by increased levels of trehalose in hemolymph and enhanced phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α). Moreover, upregulation of triglycerides via a knockdown of fliI was reversed by a knockdown of desat1 in the fat body of flies. These results indicate that fliI suppresses the expression of desat1, thereby inhibiting the development of obesity; fliI may, thus, serve as a novel therapeutic target in obesity and metabolic diseases.

PubMed ID
PubMed Central ID
PMC6030243 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Cells
    Title
    Molecules and Cells
    ISBN/ISSN
    1016-8478
    Data From Reference
    Alleles (7)
    Genes (3)
    Human Disease Models (1)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (4)