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Citation
Xun, Q., Bi, C., Cui, X., Wu, H., Wang, M., Liao, Y., Wang, R., Xie, H., Shen, Z., Fang, M. (2018). MagT1 is essential for Drosophila development through the shaping of Wingless and Decapentaplegic signaling pathways.  Biochem. Biophys. Res. Commun. 503(2): 1148--1153.
FlyBase ID
FBrf0239788
Publication Type
Research paper
Abstract

Magnesium transporter subtype 1 (MagT1) is a magnesium membrane transporter with channel like properties. We have previously identified MagT1 (CG7830) in Drosophila genome and characterized its protein product by electrophysiological means. Here, we report the generation of fly MagT1 mutants and show that MagT1 is essential for early embryonic development. In wings and primordial wings, by clonal analysis and RNAi knock down of MagT1, we have found that loss of MagT1 results in enhanced/ectopic Wingless (Wg, a fly Wnt) signaling and disrupted Decapentaplegic (Dpp) signaling, indicating the crucial role of MagT1 for fly development at later stages. Finally, we demonstrate directly that magnesium transportations are proportional with the MagT1 expressional levels in Drosophila S2  cells. Taken together, these findings may suggest that MagT1 is a major magnesium transporter/channel profoundly involved in fly development by affecting developmental signaling pathways, such as Wg and Dpp signaling.

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PubMed Central ID
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biochem. Biophys. Res. Commun.
    Title
    Biochemical and Biophysical Research Communications
    Publication Year
    1959-
    ISBN/ISSN
    0006-291X
    Data From Reference
    Alleles (5)
    Genes (2)
    Cell Lines (2)
    Insertions (2)
    Transgenic Constructs (1)