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Reference
Citation
Xu, J., Vanderzalm, P.J., Ludwig, M., Su, T., Tokamov, S.A., Fehon, R.G. (2018). Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner.  Dev. Cell 46(3): 271--284.e5.
FlyBase ID
FBrf0239850
Publication Type
Research paper
Abstract

The Hippo signaling pathway is an evolutionarily conserved mechanism that controls organ size in animals. Yorkie is well known as a transcriptional co-activator that functions downstream of the Hippo pathway to positively regulate transcription of genes that promote tissue growth. Recent studies have shown that increased myosin activity activates both Yorkie and its vertebrate orthologue YAP, resulting in increased nuclear localization and tissue growth. Here we show that Yorkie also can accumulate at the cell cortex in the apical junctional region. Moreover, Yorkie functions at the cortex to promote activation of myosin through a myosin regulatory light chain kinase, Stretchin-Mlck. This Yorkie function is not dependent on its transcriptional activity and is required for larval and adult tissues to achieve appropriate size. Based on these results, we suggest that Yorkie functions in a feedforward "amplifier" loop that promotes myosin activation, and thereby greater Yorkie activity, in response to tension.

PubMed ID
PubMed Central ID
PMC6086586 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Alleles (50)
    Genes (14)
    Physical Interactions (1)
    Cell Lines (1)
    Natural transposons (3)
    Insertions (5)
    Experimental Tools (7)
    Transgenic Constructs (42)