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Citation
Goto, A., Okado, K., Martins, N., Cai, H., Barbier, V., Lamiable, O., Troxler, L., Santiago, E., Kuhn, L., Paik, D., Silverman, N., Holleufer, A., Hartmann, R., Liu, J., Peng, T., Hoffmann, J.A., Meignin, C., Daeffler, L., Imler, J.L. (2018). The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.  Immunity 49(2): 225--234.e4.
FlyBase ID
FBrf0239857
Publication Type
Research paper
Abstract

Antiviral immunity in Drosophila involves RNA interference and poorly characterized inducible responses. Here, we showed that two components of the IMD pathway, the kinase dIKKβ and the transcription factor Relish, were required to control infection by two picorna-like viruses. We identified a set of genes induced by viral infection and regulated by dIKKβ and Relish, which included an ortholog of STING. We showed that dSTING participated in the control of infection by picorna-like viruses, acting upstream of dIKKβ to regulate expression of Nazo, an antiviral factor. Our data reveal an antiviral function for STING in an animal model devoid of interferons and suggest an evolutionarily ancient role for this molecule in antiviral immunity.

PubMed ID
PubMed Central ID
PMC6267954 (PMC) (EuropePMC)
Related Publication(s)
Erratum

The Kinase IKKβ Regulates a STING-and NF-κB-Dependent Antiviral Response Pathway in Drosophila.
Goto et al., 2020, Immunity 52(1): 200 [FBrf0244566]

Note

Insects Go on a STING Operation to Tackle Intracellular Invaders.
Zakovic and Levashina, 2018, Immunity 49(2): 195--197 [FBrf0239933]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunity
    Title
    Immunity
    Publication Year
    1994-
    ISBN/ISSN
    1074-7613
    Data From Reference
    Aberrations (6)
    Alleles (10)
    Genes (24)
    Cell Lines (2)
    Natural transposons (1)
    Insertions (3)
    Transgenic Constructs (1)