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Tran, N.L., Goldsmith, S.L., Dimitriadou, A., Takaesu, N.T., Consoulas, C., Newfeld, S.J. (2018). CORL Expression and Function in Insulin Producing Neurons Reversibly Influences Adult Longevity in Drosophila.  G3 (Bethesda) 8(9): 2979--2990.
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Research paper

CORL proteins (known as SKOR in mice, Fussel in humans and fussel in Flybase) are a family of CNS specific proteins related to Sno/Ski oncogenes. Their developmental and adult roles are largely unknown. A Drosophila CORL (dCORL) reporter gene is expressed in all Drosophila insulin-like peptide 2 (dILP2) neurons of the pars intercerebralis (PI) of the larval and adult brain. The transcription factor Drifter is also expressed in the PI in a subset of dCORL and dILP2 expressing neurons and in several non-dILP2 neurons. dCORL mutant virgin adult brains are missing all dILP2 neurons that do not also express Drifter. This phenotype is also seen when expressing dCORL-RNAi in neurosecretory cells of the PI. dCORL mutant virgin adults of both sexes have a significantly shorter lifespan than their parental strain. This longevity defect is completely reversed by mating (lifespan increases over 50% for males and females). Analyses of dCORL mutant mated adult brains revealed a complete rescue of dILP2 neurons without Drifter. Taken together, the data suggest that dCORL participates in a neural network connecting the insulin signaling pathway, longevity and mating. The conserved sequence and CNS specificity of all CORL proteins imply that this network may be operating in mammals.

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PubMed Central ID
PMC6118311 (PMC) (EuropePMC)
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    G3 (Bethesda)
    G3 : genes - genomes - genetics
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    Aberrations (1)
    Alleles (7)
    Genes (10)
    Natural transposons (1)
    Insertions (4)
    Transgenic Constructs (2)