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Citation
Kachaev, Z.M., Lebedeva, L.A., Kozlov, E.N., Toropygin, I.Y., Schedl, P., Shidlovskii, Y.V. (2018). Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila.  Cell Cycle 17(14): 1708--1720.
FlyBase ID
FBrf0239974
Publication Type
Research paper
Abstract

Paip2 (Poly(A)-binding protein - interacting protein 2) is a conserved metazoan-specific protein that has been implicated in regulating the translation and stability of mRNAs. However, we have found that Paip2 is not restricted to the cytoplasm but is also found in the nucleus in Drosophila embryos, salivary glands, testes, and tissue culture cells. Nuclear Paip2 is associated with chromatin, and in chromatin immunoprecipitation experiments it maps to the promoter regions of active genes. However, this chromatin association is indirect, as it is RNA-dependent. Thus, Paip2 is one more item in the growing list of translation factors that are recruited to mRNAs co-transcriptionally.

PubMed ID
PubMed Central ID
PMC6133343 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Cycle
    Title
    Cell Cycle
    Publication Year
    2002
    ISBN/ISSN
    1538-4101 1551-4005
    Data From Reference
    Genes (5)
    Physical Interactions (2)
    Cell Lines (1)