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Citation
Tseng, C.Y., Su, Y.H., Yang, S.M., Lin, K.Y., Lai, C.M., Rastegari, E., Amartuvshin, O., Cho, Y., Cai, Y., Hsu, H.J. (2018). Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool.  Stem Cell Reports 11(3): 811--827.
FlyBase ID
FBrf0240084
Publication Type
Research paper
Abstract
In developing organisms, proper tuning of the number of stem cells within a niche is critical for the maintenance of adult tissues; however, the involved mechanisms remain largely unclear. Here, we demonstrate that Thickveins (Tkv), a type I bone morphogenetic protein (BMP) receptor, acts in the Drosophila developing ovarian soma through a Smad-independent pathway to shape the distribution of BMP signal within the niche, impacting germline stem cell (GSC) recruitment and maintenance. Somatic Tkv promotes Egfr signaling to silence transcription of Dally, which localizes BMP signals on the cell surface. In parallel, Tkv promotes Hh signaling, which promotes escort cell cellular protrusions and upregulates expression of the Drosophila BMP homolog, Dpp, forming a positive feedback loop that enhances Tkv signaling and strengthens the niche boundary. Our results reveal a role for non-canonical BMP signaling in the soma during GSC establishment and generally illustrate how complex, cell-specific BMP signaling mediates niche-stem cell interactions.
PubMed ID
PubMed Central ID
PMC6135924 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Stem Cell Reports
    Title
    Stem cell reports
    ISBN/ISSN
    2213-6711
    Data From Reference
    Genes (14)