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Citation
Alpar, L., Bergantiños, C., Johnston, L.A. (2018). Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition.  Dev. Cell 46(6): 706--719.e5.
FlyBase ID
FBrf0240118
Publication Type
Research paper
Abstract
Cell competition employs comparisons of fitness to selectively eliminate cells sensed as less healthy. In Drosophila, apoptotic elimination of the weaker "loser" cells from growing wing discs is induced by a signaling module consisting of the Toll ligand Spätzle (Spz), several Toll-related receptors, and NF-κB factors. How this module is activated and restricted to competing disc cells is unknown. Here, we use Myc-induced cell competition to demonstrate that loser cell elimination requires local wing disc synthesis of Spz. We identify Spz processing enzyme (SPE) and modular serine protease (ModSP) as activators of Spz-regulated competitive signaling and show that "winner" cells trigger elimination of nearby WT cells by boosting SPE production. Moreover, Spz requires both Toll and Toll-8 to induce apoptosis of wing disc cells. Thus, during cell competition, Spz-mediated signaling is strictly confined to the imaginal disc, allowing errors in tissue fitness to be corrected without compromising organismal physiology.
PubMed ID
PubMed Central ID
PMC6156939 (PMC) (EuropePMC)
Related Publication(s)
Note
Super-Competitors Game the Fitness Sensing System.
Herrera and Bach, 2018, Dev. Cell 46(6): 672--674 [FBrf0240379]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (1)
    Alleles (56)
    Genes (24)
    Natural transposons (2)
    Insertions (10)
    Experimental Tools (6)
    Transgenic Constructs (33)