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Citation
Roed, N.K., Viola, C.M., Kristensen, O., Schluckebier, G., Norrman, M., Sajid, W., Wade, J.D., Andersen, A.S., Kristensen, C., Ganderton, T.R., Turkenburg, J.P., De Meyts, P., Brzozowski, A.M. (2018). Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.  Nat. Commun. 9(1): 3860.
FlyBase ID
FBrf0240146
Publication Type
Research paper
Abstract

The insulin/insulin-like growth factor signalling axis is an evolutionary ancient and highly conserved hormonal system involved in the regulation of metabolism, growth and lifespan in animals. Human insulin is stored in the pancreas, while insulin-like growth factor-1 (IGF-1) is maintained in blood in complexes with IGF-binding proteins (IGFBP1-6). Insect insulin-like polypeptide binding proteins (IBPs) have been considered as IGFBP-like structural and functional homologues. Here, we report structures of the Drosophila IBP Imp-L2 in its free form and bound to Drosophila insulin-like peptide 5 and human IGF-1. Imp-L2 contains two immunoglobulin-like fold domains and its architecture is unrelated to human IGFBPs, suggesting a distinct strategy for bioavailability regulation of insulin-like hormones. Similar hormone binding modes may exist in other insect vectors, as the IBP sequences are highly conserved. Therefore, these findings may open research routes towards a rational interference of transmission of diseases such as malaria, dengue and yellow fevers.

PubMed ID
PubMed Central ID
PMC6155051 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference
    Genes (3)
    Physical Interactions (5)