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Citation
Ameku, T., Yoshinari, Y., Texada, M.J., Kondo, S., Amezawa, K., Yoshizaki, G., Shimada-Niwa, Y., Niwa, R. (2018). Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.  PLoS Biol. 16(9): e2005004.
FlyBase ID
FBrf0240155
Publication Type
Research paper
Abstract
Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication.
PubMed ID
PubMed Central ID
PMC6152996 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Biol.
    Title
    PLoS Biology
    Publication Year
    2003-
    ISBN/ISSN
    1545-7885 1544-9173
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    Experimental Tools (1)
    Transgenic Constructs (23)
    Transcripts (6)