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Park, J.E., Jang, J., Lee, E.J., Kim, S.J., Yoo, H.J., Lee, S., Kang, M.J. (2018). Potential involvement of Drosophila flightless-1 in carbohydrate metabolism.  BMB Rep. 51(9): 462--467.
FlyBase ID
FBrf0240179
Publication Type
Research paper
Abstract

A previous study of ours indicated that Drosophila flightless-1 controls lipid metabolism, and that there is an accumulation of triglycerides in flightless-1 (fliI)-mutant flies, where this mutation triggers metabolic stress and an obesity phenotype. Here, with the aim of characterizing the function of FliI in metabolism, we analyzed the levels of gene expression and metabolites in fliI-mutant flies. The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway. Moreover, high-throughput RNA sequencing revealed that Drosophila FliI regulates the expression of genes related to biological processes such as chromosome organization, carbohydrate metabolism, and immune reactions. These results showed that Drosophila FliI regulates the expression of metabolic genes, and that dysregulation of the transcription controlled by FliI gives rise to metabolic stress and problems in the development and physiology of Drosophila. <up>BMB Reports 2018; 51(9): 462-467</up>.

PubMed ID
PubMed Central ID
PMC6177503 (PMC) (EuropePMC)
DOI
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BMB Rep.
    Title
    BMB Reports
    Publication Year
    2008--
    ISBN/ISSN
    1976-6696 1976-670X
    Data From Reference