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Citation
Sherrard, R.M., Morellini, N., Jourdan, N., El-Esawi, M., Arthaut, L.D., Niessner, C., Rouyer, F., Klarsfeld, A., Doulazmi, M., Witczak, J., d'Harlingue, A., Mariani, J., Mclure, I., Martino, C.F., Ahmad, M. (2018). Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen species.  PLoS Biol. 16(10): e2006229.
FlyBase ID
FBrf0240502
Publication Type
Research paper
Abstract

Exposure to man-made electromagnetic fields (EMFs), which increasingly pollute our environment, have consequences for human health about which there is continuing ignorance and debate. Whereas there is considerable ongoing concern about their harmful effects, magnetic fields are at the same time being applied as therapeutic tools in regenerative medicine, oncology, orthopedics, and neurology. This paradox cannot be resolved until the cellular mechanisms underlying such effects are identified. Here, we show by biochemical and imaging experiments that exposure of mammalian cells to weak pulsed electromagnetic fields (PEMFs) stimulates rapid accumulation of reactive oxygen species (ROS), a potentially toxic metabolite with multiple roles in stress response and cellular ageing. Following exposure to PEMF, cell growth is slowed, and ROS-responsive genes are induced. These effects require the presence of cryptochrome, a putative magnetosensor that synthesizes ROS. We conclude that modulation of intracellular ROS via cryptochromes represents a general response to weak EMFs, which can account for either therapeutic or pathological effects depending on exposure. Clinically, our findings provide a rationale to optimize low field magnetic stimulation for novel therapeutic applications while warning against the possibility of harmful synergistic effects with environmental agents that further increase intracellular ROS.

PubMed ID
PubMed Central ID
PMC6168118 (PMC) (EuropePMC)
Related Publication(s)
Note

Cryptochrome: The magnetosensor with a sinister side?
Landler and Keays, 2018, PLoS Biol. 16(10): e3000018 [FBrf0240601]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Biol.
    Title
    PLoS Biology
    Publication Year
    2003-
    ISBN/ISSN
    1545-7885 1544-9173
    Data From Reference
    Alleles (4)
    Genes (3)
    Natural transposons (1)
    Transgenic Constructs (2)