Open Close
Reference
Citation
Velentzas, P.D., Zhang, L., Das, G., Chang, T.K., Nelson, C., Kobertz, W.R., Baehrecke, E.H. (2018). The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death.  Dev. Cell 47(3): 281--293.e4.
FlyBase ID
FBrf0240552
Publication Type
Research paper
Abstract

Nutrient availability influences the production and degradation of materials that are required for cell growth and survival. Autophagy is a nutrient-regulated process that is used to degrade cytoplasmic materials and has been associated with human diseases. Solute transporters influence nutrient availability and sensing, yet we know little about how transporters influence autophagy. Here, we screen for solute transporters that are required for autophagy-dependent cell death and identify CG11665/hermes. We show that hermes is required for both autophagy during steroid-triggered salivary gland cell death and TNF-induced non-apoptotic eye cell death. hermes encodes a proton-coupled monocarboxylate transporter that preferentially transports pyruvate over lactate. mTOR signaling is elevated in hermes mutant cells, and decreased mTOR function suppresses the hermes salivary gland cell death phenotype. Hermes is most similar to human SLC16A11, a protein that was recently implicated in type 2 diabetes, thus providing a link between pyruvate, mTOR, autophagy, and possibly metabolic disorders.

PubMed ID
PubMed Central ID
PMC6219939 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for the hrm[Delta1] deletion.
Velentzas and Baehrecke, 2019.3.20, Location data for the hrm[Delta1] deletion. [FBrf0241822]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (1)
    Alleles (60)
    Genes (36)
    Natural transposons (1)
    Insertions (5)
    Experimental Tools (3)
    Transgenic Constructs (11)