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Citation
Guo, F., Holla, M., Díaz, M.M., Rosbash, M. (2018). A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila.  Neuron 100(3): 624--635.e4.
FlyBase ID
FBrf0240599
Publication Type
Research paper
Abstract

The Drosophila core circadian circuit contains distinct groups of interacting neurons that give rise to diurnal sleep-wake patterns. Previous work showed that a subset of dorsal neurons 1 (DN1s) are sleep-promoting through their inhibition of activity-promoting circadian pacemakers. Here we show that these anterior-projecting DNs (APDNs) also "exit" the circadian circuitry and communicate with the homeostatic sleep center in higher brain regions to regulate sleep and sleep-wake arousal. These APDNs connect to a small, discrete subset of tubercular-bulbar neurons, which are connected in turn to specific sleep-centric ellipsoid body (EB)-ring neurons of the central complex. Remarkably, activation of the APDNs produces sleep-like oscillations in the EB and affects arousal. The data indicate that this APDN-TuBusup-EB circuit temporally regulates sleep-wake arousal in addition to the previously defined role of the TuBu-EB circuit in vision, navigation, and attention.

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Related Publication(s)
Note

Circadian and Sleep Circuits Ring Together.
Hsu and Sehgal, 2018, Neuron 100(3): 514--516 [FBrf0240791]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (39)
    Genes (14)
    Transgenic Constructs (39)