FB2025_01 , released February 20, 2025
Reference Report
Open Close
Reference
Citation
Setiawan, L., Pan, X., Woods, A.L., O'Connor, M.B., Hariharan, I.K. (2018). The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing.  Life Sci Alliance 1(6): e201800216.
FlyBase ID
FBrf0240872
Publication Type
Research paper
Abstract
Developmental transitions are often triggered by a neuroendocrine axis and can be contingent upon multiple organs achieving sufficient growth and maturation. How the neurodendocrine axis senses the size and maturity of peripheral organs is not known. In Drosophila larvae, metamorphosis is triggered by a sharp increase in the level of the steroid hormone ecdysone, secreted by the prothoracic gland (PG). Here, we show that the BMP2/4 ortholog Dpp can function as a systemic signal to regulate developmental timing. Dpp from peripheral tissues, mostly imaginal discs, can reach the PG and inhibit ecdysone biosynthesis. As the discs grow, reduced Dpp signaling in the PG is observed, consistent with the possibility that Dpp functions in a checkpoint mechanism that prevents metamorphosis when growth is insufficient. Indeed, upon starvation early in the third larval instar, reducing Dpp signaling in the PG abrogates the critical-weight checkpoint which normally prevents pupariation under these conditions. We suggest that increased local trapping of morphogen within tissues as they grow would reduce circulating levels and hence provide a systemic readout of their growth status.
PubMed ID
PubMed Central ID
PMC6243201 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Life Sci Alliance
    Title
    Life science alliance
    ISBN/ISSN
    2575-1077
    Data From Reference
    Genes (15)