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Zhang, G., Zhang, W. (2019). Protein-protein interaction network analysis of insecticide resistance molecular mechanism in Drosophila melanogaster.  Arch. Insect Biochem. Physiol. 100(1): e21523.
FlyBase ID
FBrf0240902
Publication Type
Research paper
Abstract
The problem of resistance has not been solved fundamentally at present, because the development speed of new insecticides can not keep pace with the development speed of resistance, and the lack of understanding of molecular mechanism of resistance. Here we collected seed genes and their interacting proteins involved in insecticide resistance molecular mechanism in Drosophila melanogaster by literature mining and the String database. We identified a total of 528 proteins and 13514 protein-protein interactions. The protein interaction network was constructed by String and Pajek, and we analyzed the topological properties, such as degree centrality and eigenvector centrality. Proteasome complexes and drug metabolism-cytochrome P450 were an enrichment by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. This is the first time to explore the insecticide resistance molecular mechanism of D. melanogaster by the methods and tools of network biology, it can provide the bioinformatic foundation for further understanding the mechanisms of insecticide resistance.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Arch. Insect Biochem. Physiol.
    Title
    Archives of Insect Biochemistry and Physiology
    Publication Year
    1984-
    ISBN/ISSN
    0739-4462
    Data From Reference