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Citation
Harbison, S.T., Kumar, S., Huang, W., McCoy, L.J., Smith, K.R., Mackay, T.F.C. (2019). Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.  Behav. Genet. 49(1): 60--82.
FlyBase ID
FBrf0241121
Publication Type
Research paper
Abstract
Circadian rhythms influence physiological processes from sleep-wake cycles to body temperature and are controlled by highly conserved cycling molecules. Although the mechanistic basis of the circadian clock has been known for decades, the extent to which circadian rhythms vary in nature and the underlying genetic basis for that variation is not well understood. We measured circadian period (Ʈ) and rhythmicity index in the Drosophila Genetic Reference Panel (DGRP) and observed extensive genetic variation in both. Seven DGRP lines had sexually dimorphic arrhythmicity and one line had an exceptionally long Ʈ. Genome-wide analyses identified 584 polymorphisms in 268 genes. We observed differences among transcripts for nine genes predicted to interact among themselves and canonical clock genes in the long period line and a control. Mutations/RNAi knockdown targeting these genes also affected circadian behavior. Our observations reveal that complex genetic interactions influence high levels of variation in circadian phenotypes.
PubMed ID
PubMed Central ID
PMC6326971 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Behav. Genet.
    Title
    Behavior Genetics
    Publication Year
    1970-
    ISBN/ISSN
    0001-8244
    Data From Reference
    Aberrations (2)
    Alleles (43)
    Genes (56)
    Strains (1)
    Insertions (28)
    Transgenic Constructs (12)