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Citation
Zhao, W., Zhou, P., Gong, C., Ouyang, Z., Wang, J., Zheng, N., Gong, Z. (2019). A disinhibitory mechanism biases Drosophila innate light preference.  Nat. Commun. 10(1): 124.
FlyBase ID
FBrf0241166
Publication Type
Research paper
Abstract

Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is largely unclear. Here we show that Drosophila larval light preference behavior is regulated by a disinhibitory mechanism. In the disinhibitory circuit, a pair of GABAergic neurons exerts tonic inhibition on one pair of contralateral projecting neurons that control larval reorientation behavior. When a larva enters the light area, the reorientation-controlling neurons are disinhibited to allow reorientation to occur as the upstream inhibitory neurons are repressed by light. When the larva exits the light area, the inhibition on the downstream neurons is restored to repress further reorientation and thus prevents the larva from re-entering the light area. We suggest that disinhibition may serve as a common neural mechanism for animal innate preference behavior.

PubMed ID
PubMed Central ID
PMC6328558 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Author Correction: A disinhibitory mechanism biases Drosophila innate light preference.
Zhao et al., 2019, Nat. Commun. 10(1): 546 [FBrf0241348]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference