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Citation
Weigelt, C.M., Hahn, O., Arlt, K., Gruhn, M., Jahn, A.J., Eßer, J., Werner, J.A., Klein, C., Büschges, A., Grönke, S., Partridge, L. (2019). Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster.  Life Sci Alliance 2(1): e201800149.
FlyBase ID
FBrf0241271
Publication Type
Research paper
Abstract

miRNAs are small, non-coding RNAs that regulate gene expression post-transcriptionally. We used small RNA sequencing to identify tissue-specific miRNAs in the adult brain, thorax, gut, and fat body of Drosophila melanogaster One of the most brain-specific miRNAs that we identified was miR-210, an evolutionarily highly conserved miRNA implicated in the regulation of hypoxia in mammals. In Drosophila, we show that miR-210 is specifically expressed in sensory organs, including photoreceptors. miR-210 knockout mutants are not sensitive toward hypoxia but show progressive degradation of photoreceptor cells, accompanied by decreased photoreceptor potential, demonstrating an important function of miR-210 in photoreceptor maintenance and survival.

PubMed ID
PubMed Central ID
PMC6343102 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Life Sci Alliance
    Title
    Life science alliance
    ISBN/ISSN
    2575-1077
    Data From Reference
    Aberrations (1)
    Alleles (15)
    Genes (13)
    Polypeptides (1)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (11)