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Citation
Sato, M., Yasugi, T., Trush, O. (2019). Temporal patterning of neurogenesis and neural wiring in the fly visual system.  Neurosci. Res. 138(): 49--58.
FlyBase ID
FBrf0241276
Publication Type
Review
Abstract

During neural development, a wide variety of neurons are produced in a highly coordinated manner and form complex and highly coordinated neural circuits. Temporal patterning of neuron type specification plays very important roles in orchestrating the production and wiring of neurons. The fly visual system, which is composed of the retina and the optic lobe of the brain, is an outstanding model system to study temporal patterning and wiring of the nervous system. All of the components of the fly visual system are topographically connected, and each ommatidial unit in the retina corresponds to a columnar unit in the optic lobe. In the retina, the wave of differentiation follows the morphogenetic furrow, which progresses in a posterior-to-anterior direction. At the same time, differentiation of the optic lobe also accompanies the wave of differentiation or temporally coordinated neurogenesis. Thus, temporal patterning plays important roles in establishing topographic connections throughout the fly visual system. In this article, we review how neuronal differentiation and connectivity are orchestrated in the fly visual system by temporal patterning mechanisms.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neurosci. Res.
    Title
    Neuroscience Research
    Publication Year
    1984-
    ISBN/ISSN
    0168-0102
    Data From Reference
    Genes (26)