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Boda, A., Lőrincz, P., Takáts, S., Csizmadia, T., Tóth, S., Kovács, A.L., Juhász, G. (2019). Drosophila Arl8 is a general positive regulator of lysosomal fusion events.  Biochim Biophys Acta Mol Cell Res 1866(4): 533--544.
FlyBase ID
FBrf0241370
Publication Type
Research paper
Abstract
The small GTPase Arl8 is known to be involved in the periphery-directed motility of lysosomes. However, the overall importance of moving these vesicles is still poorly understood. Here we show that Drosophila Arl8 is required not only for the proper distribution of lysosomes, but also for autophagosome-lysosome fusion in starved fat cells, endosome-lysosome fusion in garland nephrocytes, and developmentally programmed secretory granule degradation (crinophagy) in salivary gland cells. Moreover, proper Arl8 localization to lysosomes depends on the shared subunits of the BLOC-1 and BORC complexes, which also promote autophagy and crinophagy. In conclusion, we demonstrate that Arl8 is responsible not only for positioning lysosomes but also acts as a general lysosomal fusion factor.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biochim Biophys Acta Mol Cell Res
    Title
    Biochimica et biophysica acta. Molecular cell research.
    ISBN/ISSN
    1879-2596 0167-4889
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