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Citation
Johnson, H.E., Toettcher, J.E. (2019). Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo.  Dev. Cell 48(3): 361--370.e3.
FlyBase ID
FBrf0241392
Publication Type
Research paper
Abstract

The Erk mitogen-activated protein kinase plays diverse roles in animal development. Its widespread reuse raises a conundrum: when a single kinase like Erk is activated, how does a developing cell know which fate to adopt? We combine optogenetic control with genetic perturbations to dissect Erk-dependent fates in the early Drosophila embryo. We find that Erk activity is sufficient to "posteriorize" 88% of the embryo, inducing gut endoderm-like gene expression and morphogenetic movements in all cells within this region. Gut endoderm fate adoption requires at least 1 h of signaling, whereas a 30-min Erk pulse specifies a distinct ectodermal cell type, intermediate neuroblasts. We find that the endoderm-ectoderm cell fate switch is controlled by the cumulative load of Erk activity, not the duration of a single pulse. The fly embryo thus harbors a classic example of dynamic control, where the temporal profile of Erk signaling selects between distinct physiological outcomes.

PubMed ID
PubMed Central ID
PMC6394837 (PMC) (EuropePMC)
Related Publication(s)
Note

Developmental Erk Signaling Illuminated.
Gagliardi and Pertz, 2019, Dev. Cell 48(3): 289--290 [FBrf0241463]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Genes (12)