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Strassburger, K., Kang, E., Teleman, A.A. (2019). Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.  PLoS ONE 14(2): e0198149.
FlyBase ID
FBrf0241439
Publication Type
Research paper
Abstract
Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8.
PubMed ID
PubMed Central ID
PMC6368284 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Aberrations (1)
    Alleles (14)
    Genes (6)
    Human Disease Models (1)
    Cell Lines (1)
    Natural transposons (2)
    Insertions (3)
    Experimental Tools (3)
    Transgenic Constructs (11)