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Citation
Böhme, M.A., McCarthy, A.W., Grasskamp, A.T., Beuschel, C.B., Goel, P., Jusyte, M., Laber, D., Huang, S., Rey, U., Petzoldt, A.G., Lehmann, M., Göttfert, F., Haghighi, P., Hell, S.W., Owald, D., Dickman, D., Sigrist, S.J., Walter, A.M. (2019). Rapid active zone remodeling consolidates presynaptic potentiation.  Nat. Commun. 10(1): 1085.
FlyBase ID
FBrf0241731
Publication Type
Research paper
Abstract

Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables memory formation. Postsynaptic plasticity targets neurotransmitter receptors, but presynaptic mechanisms regulating the neurotransmitter release apparatus remain largely enigmatic. By studying Drosophila neuromuscular junctions (NMJs) we show that AZs consist of nano-modular release sites and identify a molecular sequence that adds modules within minutes of inducing homeostatic plasticity. This requires cognate transport machinery and specific AZ-scaffolding proteins. Structural remodeling is not required for immediate potentiation of neurotransmitter release, but necessary to sustain potentiation over longer timescales. Finally, mutations in Unc13 disrupting homeostatic plasticity at the NMJ also impair short-term memory when central neurons are targeted, suggesting that both plasticity mechanisms utilize Unc13. Together, while immediate synaptic potentiation capitalizes on available material, it triggers the coincident incorporation of modular release sites to consolidate synaptic potentiation.

PubMed ID
PubMed Central ID
PMC6403334 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference