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Citation
Werthebach, M., Stewart, F.A., Gahlen, A., Mettler-Altmann, T., Akhtar, I., Maas-Enriquez, K., Droste, A., Eichmann, T.O., Poschmann, G., Stühler, K., Beller, M. (2019). Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf.  Cell Rep. 26(13): 3726--3740.e7.
FlyBase ID
FBrf0241891
Publication Type
Research paper
Abstract

Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral lipids. The increasing number of characterized LD-associated proteins attained LDs with hitherto unexpected functions on top of their classical role as energy depot. Here, we characterize the LD-associated protein CG9186 of Drosophila by a CRISPR/Cas9-derived mutant fly line. While the mutant flies only showed a mild triacylglycerol storage phenotype, they were highly protected from desiccation stress, likely linked to a reduced locomotor activity and altered cuticular hydrocarbons. Both parameters depend on juvenile hormone (JH) signaling. Together with an observed interaction between CG9186 and JH-degrading enzymes, our results suggest that CG9186 participates in endocrine physiology regulation. In support of this hypothesis, CG9186 mutant flies show an altered expression of JH target genes and fail to adjust their developmental rate to dietary yeast-to-sugar ratio changes. Our results thus link LDs to organismic physiology regulation.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
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