Open Close
Reference
Citation
Tang, R., Chen, X., Dang, T., Deng, Y., Zou, Z., Liu, Q., Gong, G., Song, S., Ma, F., Huang, L., Wang, Z. (2019). Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster.  Food Funct. 10(7): 4231--4241.
FlyBase ID
FBrf0242953
Publication Type
Research paper
Abstract

The fruits of Lycium barbarum are considered medicinal foods with high nutritional value and bioactivity. In this study, we aimed to evaluate the effect of a crude L. barbarum polysaccharide (LBP) and two derived fractions, LBP-1 and LBP-2, on the lifespan of Drosophila melanogaster (fruit fly). The average lifespan of fruit flies was extended by supplementing their diet with either of the three LBP preparations. In vivo analysis of antioxidant activities detected increased superoxide dismutase (SOD) and catalase (CAT) activities and decreased malondialdehyde (MDA) levels. Dietary LBP supplements significantly reduced the mortality rate of fruit flies induced by paraquat and hydrogen peroxide. Importantly, the strongest anti-aging activity was exhibited by the LBP-2 fraction, containing arabinogalactan with a molecular weight of 9 × 104 Da. Further studies showed that the anti-aging activity of LBP was, at least in part, mediated by an age-related signaling pathway (MAPK, TOR, S6K) and the expression of longevity genes (Hep, MTH, and Rpn11).

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Food Funct.
    Title
    Food & function
    ISBN/ISSN
    2042-6496 2042-650X
    Data From Reference
    Genes (7)