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Citation
Ueoka, I., Pham, H.T.N., Matsumoto, K., Yamaguchi, M. (2019). Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents.  Int. J. Mol. Sci. 20(17): E4071.
FlyBase ID
FBrf0243304
Publication Type
Review
Abstract

Whole exome analyses have identified a number of genes associated with autism spectrum disorder (ASD) and ASD-related syndromes. These genes encode key regulators of synaptogenesis, synaptic plasticity, cytoskeleton dynamics, protein synthesis and degradation, chromatin remodeling, transcription, and lipid homeostasis. Furthermore, in silico studies suggest complex regulatory networks among these genes. Drosophila is a useful genetic model system for studies of ASD and ASD-related syndromes to clarify the in vivo roles of ASD-associated genes and the complex gene regulatory networks operating in the pathogenesis of ASD and ASD-related syndromes. In this review, we discuss what we have learned from studies with vertebrate models, mostly mouse models. We then highlight studies with Drosophila models. We also discuss future developments in the related field.

PubMed ID
PubMed Central ID
PMC6747505 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Correction: Ueoka, I., et al. Autism Spectrum Disorder-Related Syndromes: Modeling with Drosophila and Rodents. Int. J. Mol. Sci. 2019, 20, 4071.
Ueoka et al., 2020, Int. J. Mol. Sci. 21(21): E8093 [FBrf0247122]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Int. J. Mol. Sci.
    Title
    International journal of molecular sciences
    ISBN/ISSN
    1422-0067
    Data From Reference