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Citation
Wilinski, D., Winzeler, J., Duren, W., Persons, J.L., Holme, K.J., Mosquera, J., Khabiri, M., Kinchen, J.M., Freddolino, P.L., Karnovsky, A., Dus, M. (2019). Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster.  Nat. Commun. 10(1): 4052.
FlyBase ID
FBrf0243388
Publication Type
Research paper
Abstract

Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior.

PubMed ID
PubMed Central ID
PMC6731244 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference