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Citation
Yang, Y., Klionsky, D.J. (2020). A novel role of UBQLNs (ubiquilins) in regulating autophagy, MTOR signaling and v-ATPase function.  Autophagy 16(1): 1--2.
FlyBase ID
FBrf0244335
Publication Type
Note
Abstract

UBQLNs (ubiquilins) are highly conserved proteins across species, characterized by interactions with proteasomes and ubiquitinated proteins via UBA and UBL domains, respectively. The role of UBQLNs as chaperone proteins of the ubiquitin-proteasome system (UPS) is well-defined; however, the connections between UBQLNs and autophagy remain unclear. A recent study published in Nature Cell Biology from Dr. Hugo J. Bellen's lab showed a novel role of UBQLNs in macroautophagy/autophagy regulation through v-ATPase-MTOR signaling using Drosophila and mammalian neuronal cells. Notably, the highlighted article also investigated the autophagy phenotype of a common amyotrophic lateral sclerosis (ALS)-associated mutation in the gene encoding UBQLN2, demonstrating the contribution of abnormal v-ATPase-MTOR-mediated autophagy in ALS pathogenesis.

PubMed ID
PubMed Central ID
PMC6984483 (PMC) (EuropePMC)
Related Publication(s)
Research paper

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
Şentürk et al., 2019, Nat. Cell Biol. 21(3): 384--396 [FBrf0241650]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Autophagy
    Title
    Autophagy
    Publication Year
    2005-
    ISBN/ISSN
    1554-8627 1554-8635
    Data From Reference