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Citation
Fast, D., Petkau, K., Ferguson, M., Shin, M., Galenza, A., Kostiuk, B., Pukatzki, S., Foley, E. (2020). Vibrio cholerae-Symbiont Interactions Inhibit Intestinal Repair in Drosophila.  Cell Rep. 30(4): 1088--1100.e5.
FlyBase ID
FBrf0244683
Publication Type
Research paper
Abstract

Pathogen-mediated damage to the intestinal epithelium activates compensatory growth and differentiation repair programs in progenitor cells. Accelerated progenitor growth replenishes damaged tissue and maintains barrier integrity. Despite the importance of epithelial renewal to intestinal homeostasis, we know little about the effects of pathogen-commensal interactions on progenitor growth. We find that the enteric pathogen Vibrio cholerae blocks critical growth and differentiation pathways in Drosophila progenitors, despite extensive damage to epithelial tissue. We show that the inhibition of epithelial repair requires interactions between the Vibrio cholerae type six secretion system and a community of common symbiotic bacteria, as elimination of the gut microbiome is sufficient to restore homeostatic growth in infected intestines. This work highlights the importance of pathogen-symbiont interactions for intestinal immune responses and outlines the impact of the type six secretion system on pathogenesis.

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Related Publication(s)
Note

The Microbiome Sets the Stage for Cholera.
Sokol and Newton, 2020, Trends Microbiol. 28(6): 430--432 [FBrf0245677]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference
    Genes (8)
    Human Disease Models (1)