Open Close
Reference
Citation
Li, X., Rommelaere, S., Kondo, S., Lemaitre, B. (2020). Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage.  Immunity 52(2): 374--387.e6.
FlyBase ID
FBrf0244907
Publication Type
Research paper
Abstract

Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the insect kidney. This lipid purge was mediated by a stress-induced lipid-binding protein, Materazzi, which was enriched in Malpighian tubules. Flies lacking materazzi had higher hemolymph concentrations of reactive oxygen species (ROS) and increased lipid peroxidation. These flies also displayed Malpighian tubule dysfunction and were susceptible to infections and environmental stress. Feeding flies with antioxidants rescued the materazzi phenotype, indicating that the main role of Materazzi is to protect the organism from damage caused by stress-induced ROS. Our findings suggest that purging hemolymphatic lipids presents a physiological adaptation to protect host tissues from excessive ROS during immune and stress responses, a process that is likely to apply to other organisms.

PubMed ID
PubMed Central ID
Related Publication(s)
Note

Delipidation Destresses Drosophila.
Lee, 2020, Immunity 52(2): 215--217 [FBrf0244990]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunity
    Title
    Immunity
    Publication Year
    1994-
    ISBN/ISSN
    1074-7613
    Data From Reference